⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9439880 | 0.63 | — | — | |
| SCHEMBL1549773 | 0.62 | — | — | |
| SCHEMBL7973609 | 0.62 | — | — | |
| SCHEMBL1549774 | 0.62 | — | — | |
| SCHEMBL2255302 | 0.62 | — | — | |
| SCHEMBL11513404 | 0.61 | — | — | |
| SCHEMBL940708 | 0.59 | — | — | |
| SCHEMBL23198641 | 0.57 | — | — | |
| SCHEMBL8675904 | 0.56 | — | — | |
| SCHEMBL7104332 | 0.47 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104844507-A | Application of quinolinone compounds to inhibit growth of alga and algicide for inhibiting growth of alga | UNIV HUAZHONG NORMAL | 2015-08-19 | — | — | CN | claimed |
| CN-103508950-A | 4-hydroxy-2-quinolinone compounds containing imine structure, and preparation and application thereof | UNIV NANKAI | 2014-01-15 | — | — | CN | claimed |
| US-20040254344-A1 | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues | XENOPORT | 2004-12-16 | — | — | US | claimed |
| EP-1412324-A4 | AMINO ACID CONJUGATES PROVIDING FOR SUSTAINED SYSTEMIC CONCENTRATIONS OF GABA ANALOGUES | XENOPORT INC (US) | 2004-09-29 | — | — | EP | claimed |
| EP-1412324-A2 | AMINO ACID CONJUGATES PROVIDING FOR SUSTAINED SYSTEMIC CONCENTRATIONS OF GABA ANALOGUES | Xenoport, Inc. (US) | 2004-04-28 | — | — | EP | claimed |
| US-20030181390-A1 | Amino acid conjugates providing for sustained systemic concentrations of GABA analogues | XENOPORT, INC. | 2003-09-25 | — | — | US | claimed |
| WO-2002100344-A2 | AMINO ACID CONJUGATES PROVIDING FOR SUSTAINED SYSTEMIC CONCENTRATIONS OF GABA ANALOGUES | XENOPORT, INC. (US) | 2002-12-19 | — | — | WO | claimed |
| WO-2024105016-A1 | NOVEL BICYCLIC[1,2,4]TRIAZOLONE DERIVATIVES AS NEGATIVE ALLOSTERIC MODULATORS OF MGLU7 RECEPTORS | ADDEX PHARMA S.A. (CH) | 2024-05-23 | — | — | WO | disclosed |
| WO-2024105018-A1 | NOVEL PYRROLO[1,2-d][1,2,4]TRIAZINONE DERIVATIVES AS NEGATIVE ALLOSTERIC MODULATORS OF MGLU7 RECEPTORS | ADDEX PHARMA S.A. (CH) | 2024-05-23 | — | — | WO | disclosed |
| WO-2024105021-A1 | NOVEL PYRROLO[1,2-d][1,2,4]TRIAZIN-1-ONE DERIVATIVES AS NEGATIVE ALLOSTERIC MODULATORS OF MGLU7 RECEPTORS | ADDEX PHARMA S.A. (CH) | 2024-05-23 | — | — | WO | disclosed |
| EP-4337643-A1 | SUBSTITUTED HETEROBICYCLIC DERIVATIVES AS NEGATIVE ALLOSTERIC MODULATORS OF MGLU7 RECEPTOR | Addex Pharma S.A (CH) | 2024-03-20 | — | — | EP | disclosed |
| EP-4337664-A1 | FUSED HETEROCYCLIC DERIVATIVES AS NEGATIVE ALLOSTERIC MODULATORS OF MGLU7 RECEPTOR | Addex Pharma S.A (CH) | 2024-03-20 | — | — | EP | disclosed |
| CN-111527090-B | Pyrazolo-pyrrolo-pyrimidine-dione derivatives as P2X3 inhibitors | 拜耳公司 | 2023-05-26 | — | — | CN | disclosed |
| EP-1412324-A4 | AMINO ACID CONJUGATES PROVIDING FOR SUSTAINED SYSTEMIC CONCENTRATIONS OF GABA ANALOGUES | XENOPORT INC (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-1412324-A2 | AMINO ACID CONJUGATES PROVIDING FOR SUSTAINED SYSTEMIC CONCENTRATIONS OF GABA ANALOGUES | Xenoport, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| CN-1473163-A | Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors | — | 2004-02-04 | — | — | CN | disclosed |
| US-20030181390-A1 | Amino acid conjugates providing for sustained systemic concentrations of GABA analogues | XENOPORT, INC. | 2003-09-25 | — | — | US | disclosed |
| WO-2002100344-A2 | AMINO ACID CONJUGATES PROVIDING FOR SUSTAINED SYSTEMIC CONCENTRATIONS OF GABA ANALOGUES | XENOPORT, INC. (US) | 2002-12-19 | — | — | WO | disclosed |
| CN-1081676-A | The indoles and the indazole derivatives that are used for the treatment and the prevention of cerebral disorders, their preparation and application | SANKYO CO (JP) | 1994-02-09 | — | — | CN | disclosed |
| EP-0562832-A1 | Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use | SANKYO COMPANY LIMITED (JP) | 1993-09-29 | — | — | EP | disclosed |