⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29266042 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL22322221 | 0.79 | — | — | |
| SCHEMBL28579308 | 0.73 | — | — | |
| SCHEMBL29118921 | 0.72 | — | — | |
| SCHEMBL45303 | 0.72 | — | — | |
| SCHEMBL5943563 | 0.72 | — | — | |
| SCHEMBL14862507 | 0.72 | — | — | |
| SCHEMBL4575224 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL22443016 | 0.69 | — | — | |
| SCHEMBL15402846 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3980010-A1 | 2,3,5-TRISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS | Arcus Biosciences, Inc. (US) | 2022-04-13 | — | — | EP | disclosed |
| WO-2020247496-A1 | 2,3,5-TRISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS | ARCUS BIOSCIENCES, INC. (US) | 2020-12-10 | — | — | WO | disclosed |
| EP-3212641-A1 | THIAZOLES AS MODULATORS OF RORyt | Janssen Pharmaceutica NV (BE) | 2017-09-06 | — | — | EP | disclosed |
| EP-3212642-A1 | AMIDE SUBSTITUTED THIAZOLES AS MODULATORS OF RORyT | Janssen Pharmaceutica NV (BE) | 2017-09-06 | — | — | EP | disclosed |
| WO-2016069976-A1 | THIAZOLES AS MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2016-05-06 | — | — | WO | disclosed |
| WO-2016069978-A1 | AMIDE SUBSTITUTED THIAZOLES AS MODULATORS OF RORγT | JANSSEN PHARMACEUTICA NV (BE) | 2016-05-06 | — | — | WO | disclosed |
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |
| EP-1381609-A1 | 5-HALOGEN-6-PHENYL-7-FLUOROALKYLAMINO-TRIAZOLOPYRIMIDINES AS FUNGICIDES | BASF AKTIENGESELLSCHAFT (DE) | 2004-01-21 | — | — | EP | disclosed |
| WO-2002083676-A1 | 5-HALOGEN-6-PHENYL-7-FLUORALKYLAMINO-TRIAZOLOPYRIMIDINES AS FUNGICIDES | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-24 | — | — | WO | disclosed |