Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.46 |
| ▸ | FLT1 | P17948 | 3/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | YES1 | P07947 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | ABL2 | P42684 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.46 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.46 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13636097 | 0.92 | KDR (0.48) | KDRPDGFRBFLT1PDGFRAABL1 | |
| SCHEMBL4280386 | 0.91 | KDR (0.52) | KDRPDGFRBFLT1PDGFRAABL1 | |
| SCHEMBL3681543 | 0.88 | KDR (0.49) | KDRPDGFRBFLT1MAPTAURKA | |
| SCHEMBL13636105 | 0.86 | KDR (0.47) | KDRPDGFRBFLT1MAPTAURKA | |
| SCHEMBL3812516 | 0.83 | KDR (0.49) | KDRPDGFRBFLT1PDGFRAABL1 | |
| SCHEMBL4285694 | 0.82 | KDR (0.51) | KDRPDGFRBFLT1PDGFRAABL1 | |
| SCHEMBL13636110 | 0.81 | MAPT (0.43) | KDRMAPT | |
| SCHEMBL13639085 | 0.79 | KDR (0.48) | KDRPDGFRBFLT1PDGFRAABL1 | |
| SCHEMBL4293238 | 0.78 | KDR (0.55) | KDRPDGFRBFLT1PDGFRAABL1 | |
| SCHEMBL4293264 | 0.78 | KDR (0.53) | KDRPDGFRBFLT1MAPTAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162445-A1 | HETEROBICYCLIC COMPOUNDS AS KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008150015-A1 | HETEROBICYCLIC COMPOUNDS AS KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-11 | — | — | WO | disclosed |