Haloxyfop

Haloxyfop

SCHEMBL3675562

C[C@H](Oc1ccc(Oc2ncc(C(F)(F)F)cc2Cl)cc1)C(=O)O

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.65
LMNA P02545 6/20 0.61
FFAR1 O14842 1/20 0.60
ALDH1A1 P00352 3/20 0.60
LIPE Q05469 1/20 0.60
KMT2A Q03164 3/20 0.56
MEN1 O00255 2/20 0.56
RAB9A P51151 1/20 0.54
HTT P42858 3/20 0.53
MAPT P10636 3/20 0.53
XBP1 P17861 2/20 0.53
NPSR1 Q6W5P4 1/20 0.53
ATM Q13315 1/20 0.52
POLB P06746 1/20 0.52
HPGD P15428 2/20 0.51
KDM4E B2RXH2 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Haloxyfop SCHEMBL9140176 1.00 SMN1; SMN2 (0.65) SMN1; SMN2LMNAFFAR1ALDH1A1LIPE
Haloxyfop SCHEMBL29426466 1.00 SMN1; SMN2 (0.65) SMN1; SMN2LMNAFFAR1ALDH1A1LIPE
Haloxyfop SCHEMBL1560810 1.00 SMN1; SMN2 (0.65) SMN1; SMN2LMNAFFAR1ALDH1A1LIPE
Haloxyfop SCHEMBL33627 1.00 SMN1; SMN2 (0.65) SMN1; SMN2LMNAFFAR1ALDH1A1LIPE
Haloxyfop SCHEMBL29792114 1.00 SMN1; SMN2 (0.65) SMN1; SMN2LMNAFFAR1ALDH1A1LIPE
Haloxyfop-R-Methyl SCHEMBL119996 1.00 SMN1; SMN2 (0.65) SMN1; SMN2LMNAFFAR1ALDH1A1LIPE
Haloxyfop-R-Methyl SCHEMBL29730427 1.00 SMN1; SMN2 (0.65) SMN1; SMN2LMNAFFAR1ALDH1A1LIPE
Haloxyfop-R-Methyl SCHEMBL11015046 0.99 SMN1; SMN2 (0.64) SMN1; SMN2LMNAFFAR1ALDH1A1LIPE
Haloxyfop SCHEMBL9362492 0.99 SMN1; SMN2 (0.64) SMN1; SMN2LMNAFFAR1ALDH1A1LIPE
Haloxyfop SCHEMBL9363165 0.99 SMN1; SMN2 (0.64) SMN1; SMN2LMNAFFAR1ALDH1A1LIPE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210254056-A1 IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS CAMP4 THERAPEUTICS CORPORATION 2021-08-19 US disclosed
US-20180007899-A1 HERBICIDAL COMPOSITIONS COMPRISING OXYFLUORFEN AND HALOXYFOP DOW AGROSCIENCES LLC 2018-01-11 US disclosed
US-20140323298-A1 HERBICIDAL COMPOSITIONS COMPRISING OXYFLUORFEN AND HALOXYFOP DOW AGROSCIENCES LLC (US) 2014-10-30 US disclosed
US-20100075854-A1 HERBICIDE COMBINATION COMPRISING DIMETHOSXYTRIAZINYL-SUBSTITUTED DIFLUOROMETHANESULFONYLANILIDES BAYER CROPSCIENCE AG (DE) 2010-03-25 US disclosed
US-5258521-A Etherification of methyl 2-chloropropionate with substituted phenol by dehydrohalogenation TOSOH CORPORATION (JP) 1993-11-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140323298-A1 HERBICIDAL COMPOSITIONS COMPRISING OXYFLUORFEN AND HALOXYFOP CYP4F3, PHF2, ASF1A SMN1; SMN2 2908/4885LMNA 3719/4885FFAR1 1271/4885
US-20180007899-A1 HERBICIDAL COMPOSITIONS COMPRISING OXYFLUORFEN AND HALOXYFOP CYP4F3, PHF2, ASF1A SMN1; SMN2 2908/4885LMNA 3719/4885FFAR1 1271/4885
US-20100075854-A1 HERBICIDE COMBINATION COMPRISING DIMETHOSXYTRIAZINYL-SUBSTITUTED DIFLUOROMETHANESULFONYLANILIDES DDT, CYP4F12, CYP4F2 SMN1; SMN2 4642/4885LMNA 4565/4885FFAR1 1750/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.