Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.70 |
| ▸ | JAK3 | P52333 | 3/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3509330 | 0.90 | JAK2 (0.72) | JAK2JAK3KCNH2 | |
| SCHEMBL13465102 | 0.90 | JAK2 (0.72) | JAK2JAK3KCNH2 | |
| SCHEMBL13139195 | 0.89 | JAK2 (0.71) | JAK2JAK3KCNH2 | |
| SCHEMBL3510281 | 0.89 | JAK2 (0.71) | JAK2JAK3KCNH2 | |
| SCHEMBL13270115 | 0.87 | JAK2 (0.78) | JAK2JAK3KCNH2 | |
| SCHEMBL13270114 | 0.87 | JAK2 (0.68) | JAK2JAK3KCNH2 | |
| SCHEMBL3509253 | 0.87 | JAK2 (0.70) | JAK2JAK3KCNH2 | |
| SCHEMBL3510742 | 0.87 | JAK2 (0.70) | JAK2JAK3KCNH2 | |
| SCHEMBL3509800 | 0.87 | JAK2 (0.68) | JAK2JAK3KCNH2 | |
| SCHEMBL3508791 | 0.86 | JAK2 (0.65) | JAK2JAK3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-B1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME (US) | 2012-10-17 | — | — | EP | claimed |
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | claimed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | claimed |