Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 14/20 | 0.66 |
| ▸ | AURKA | O14965 | 7/20 | 0.66 |
| ▸ | KIT | P10721 | 5/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL546419 | 0.89 | AURKB (0.79) | AURKBAURKAKITKDRFLT3 | |
| SCHEMBL545492 | 0.89 | AURKB (0.75) | AURKBAURKAKITKDRFLT3 | |
| SCHEMBL545713 | 0.88 | AURKB (0.77) | AURKBAURKAKITKDRFLT3 | |
| SCHEMBL546920 | 0.88 | AURKB (0.70) | AURKBAURKAKITKDRFLT3 | |
| SCHEMBL546241 | 0.87 | AURKB (0.76) | AURKBAURKAKITKDRFLT3 | |
| SCHEMBL546142 | 0.86 | AURKB (0.68) | AURKBAURKAKITKDRFLT3 | |
| SCHEMBL545774 | 0.86 | AURKB (0.79) | AURKBAURKAKITKDRFLT3 | |
| SCHEMBL545808 | 0.85 | AURKB (0.72) | AURKBAURKAKITKDRFLT3 | |
| SCHEMBL545600 | 0.85 | AURKB (0.66) | AURKBAURKAKITKDRFLT3 | |
| SCHEMBL545612 | 0.85 | AURKB (0.66) | AURKBAURKAKITKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170834-A1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AS INHIBITORS OF PROTEIN KINASES | Abbott Laboratories (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009012312-A1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2009-01-22 | — | — | WO | disclosed |