Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 19/20 | 0.89 |
| ▸ | INSR | P06213 | 18/20 | 0.89 |
| ▸ | IGF1R | P08069 | 12/20 | 0.89 |
| ▸ | AURKA | O14965 | 4/20 | 0.74 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.74 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.69 |
| ▸ | PLK4 | O00444 | 2/20 | 0.69 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.69 |
| ▸ | PRKCG | P05129 | 2/20 | 0.69 |
| ▸ | ROS1 | P08922 | 2/20 | 0.69 |
| ▸ | FER | P16591 | 2/20 | 0.69 |
| ▸ | LTK | P29376 | 2/20 | 0.69 |
| ▸ | FRK | P42685 | 2/20 | 0.69 |
| ▸ | MST1R | Q04912 | 2/20 | 0.69 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.69 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.69 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.69 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.69 |
| ▸ | JAK2 | O60674 | 1/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3513107 | 0.94 | ALK (1.00) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL3511488 | 0.91 | ALK (0.88) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL3514169 | 0.91 | ALK (0.82) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL31391748 | 0.90 | ALK (0.86) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL23901333 | 0.90 | ALK (0.86) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL3512875 | 0.87 | ALK (1.00) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL18142896 | 0.87 | ALK (0.90) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL3514179 | 0.86 | ALK (1.00) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL3511716 | 0.86 | ALK (1.00) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL3510546 | 0.86 | ALK (1.00) | ALKINSRIGF1RAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176231-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009013126-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-01-29 | — | — | WO | disclosed |