Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.57 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3509646 | 0.86 | JAK2 (0.60) | JAK2KCNH2JAK3 | |
| SCHEMBL3671676 | 0.82 | JAK2 (0.52) | JAK2KCNH2JAK3CHEK1 | |
| SCHEMBL3508567 | 0.79 | JAK2 (0.62) | JAK2KCNH2JAK3CHEK1 | |
| SCHEMBL3677851 | 0.79 | JAK2 (0.52) | JAK2KCNH2JAK3 | |
| SCHEMBL3671513 | 0.79 | JAK2 (0.60) | JAK2KCNH2JAK3 | |
| SCHEMBL3671965 | 0.78 | JAK2 (0.59) | JAK2KCNH2JAK3 | |
| SCHEMBL3674555 | 0.78 | JAK2 (0.57) | JAK2KCNH2JAK3 | |
| SCHEMBL3509564 | 0.78 | JAK2 (0.52) | JAK2KCNH2JAK3 | |
| SCHEMBL3667986 | 0.78 | JAK2 (0.60) | JAK2KCNH2JAK3 | |
| SCHEMBL3666667 | 0.76 | JAK2 (0.74) | JAK2KCNH2JAK3CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | claimed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | claimed |
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |