Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | CCND1 | P24385 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3510261 | 0.88 | JAK2 (0.51) | JAK2KCNH2CHEK1JAK3AURKA | |
| SCHEMBL3672229 | 0.84 | JAK2 (0.46) | JAK2KCNH2CHEK1JAK3 | |
| SCHEMBL3668318 | 0.80 | JAK2 (0.61) | JAK2KCNH2JAK3 | |
| SCHEMBL3512574 | 0.80 | JAK2 (0.53) | JAK2KCNH2CHEK1JAK3CDK4 | |
| SCHEMBL13117225 | 0.80 | JAK2 (0.47) | JAK2KCNH2CHEK1JAK3AURKA | |
| SCHEMBL1579825 | 0.79 | JAK2 (0.47) | JAK2KCNH2CHEK1JAK3 | |
| SCHEMBL3672482 | 0.79 | JAK2 (0.59) | JAK2KCNH2JAK3 | |
| SCHEMBL3673354 | 0.78 | JAK2 (0.39) | JAK2KCNH2JAK3 | |
| SCHEMBL3670403 | 0.78 | JAK2 (0.53) | JAK2KCNH2CHEK1JAK3GRM2 | |
| SCHEMBL3508268 | 0.78 | JAK2 (0.57) | JAK2KCNH2CHEK1JAK3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | claimed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | claimed |
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |