Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | RAF1 | P04049 | 1/20 | 0.58 |
| ▸ | BRAF | P15056 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4248596 | 0.91 | SMN1; SMN2 (0.71) | TAAR1TP53SMN1; SMN2MAPTTHRB | |
| SCHEMBL3638666 | 0.88 | TAAR1 (0.74) | TAAR1TP53SMN1; SMN2MAPTTHRB | |
| SCHEMBL4247984 | 0.88 | TAAR1 (0.80) | TAAR1TP53SMN1; SMN2MAPTTHRB | |
| SCHEMBL3642495 | 0.87 | TAAR1 (0.79) | TAAR1 | |
| SCHEMBL3645668 | 0.87 | TAAR1 (0.79) | TAAR1 | |
| SCHEMBL3645506 | 0.86 | TAAR1 (0.77) | TAAR1TP53SMN1; SMN2MAPTTHRB | |
| SCHEMBL29690457 | 0.82 | TAAR1 (1.00) | TAAR1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL3647615 | 0.82 | TAAR1 (1.00) | TAAR1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL4254287 | 0.81 | TAAR1 (0.68) | TAAR1RAF1BRAF | |
| SCHEMBL4254100 | 0.81 | TAAR1 (0.77) | TAAR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2182935-A1 | THE USE OF BENZAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | F. Hoffmann-Roche AG (CH) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009016088-A1 | THE USE OF BENZAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | WO | disclosed |