Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.68 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3508992 | 0.81 | JAK2 (1.00) | JAK2JAK3 | |
| SCHEMBL3510299 | 0.81 | JAK2 (1.00) | JAK2JAK3KCNH2 | |
| SCHEMBL3511304 | 0.81 | JAK2 (1.00) | JAK2JAK3KCNH2 | |
| SCHEMBL3509413 | 0.80 | JAK2 (1.00) | JAK2JAK3KCNH2 | |
| SCHEMBL3513284 | 0.79 | JAK2 (1.00) | JAK2JAK3KCNH2 | |
| SCHEMBL3512253 | 0.79 | JAK2 (0.85) | JAK2JAK3KCNH2 | |
| SCHEMBL3508881 | 0.79 | JAK2 (0.81) | JAK2JAK3KCNH2 | |
| SCHEMBL3509539 | 0.78 | JAK2 (0.79) | JAK2JAK3KCNH2 | |
| SCHEMBL3508076 | 0.78 | JAK2 (1.00) | JAK2JAK3 | |
| SCHEMBL3512007 | 0.78 | JAK2 (0.75) | JAK2JAK3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | claimed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | claimed |