SCHEMBL3677835

SCHEMBL3677835

FC(F)(c1ccc(Oc2ccc(C(F)(F)C(F)(F)c3cccc(I)c3)cc2)cc1)C(F)(F)c1cccc(I)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 2/20 0.36
TLR8 Q9NR97 2/20 0.36
NR3C1 P04150 1/20 0.35
PGR P06401 1/20 0.35
AR P10275 1/20 0.35
ESR2 Q92731 1/20 0.35
LTA4H P09960 1/20 0.35
KIF11 P52732 1/20 0.35
MAPT P10636 3/20 0.34
ALDH1A1 P00352 2/20 0.34
MEN1 O00255 1/20 0.34
MITF O75030 1/20 0.34
GAA P10253 1/20 0.34
GFER P55789 1/20 0.34
KMT2A Q03164 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
NLRP1 Q9C000 1/20 0.34
NOD2 Q9HC29 1/20 0.34
APP P05067 1/20 0.34
RAB9A P51151 4/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3671780 0.95 MAPK14 (0.34) MAPK14TLR8NR3C1PGRAR
SCHEMBL3679828 0.95 MAPK14 (0.34) MAPK14TLR8NR3C1PGRAR
SCHEMBL3671348 0.93 TLR8 (0.33) MAPK14TLR8NR3C1PGRAR
SCHEMBL3669658 0.80 CA1 (0.45) MAPK14TLR8NR3C1PGRAR
SCHEMBL3676084 0.80 AR (0.43) TLR8PGRARMAPTALDH1A1
SCHEMBL3671300 0.80 APP (0.40) ESR2LTA4HMAPTALDH1A1MEN1
SCHEMBL5240704 0.78 TSHR (0.35) ALDH1A1APPMAPK1IDO1
SCHEMBL13692793 0.76 NPC1 (0.44) LTA4HMAPTALDH1A1MEN1MITF
SCHEMBL3679342 0.75 APP (0.37) ESR2LTA4HMAPTALDH1A1MEN1
SCHEMBL3667699 0.75 APP (0.37) ESR2LTA4HMAPTALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1329444-B1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORP (JP) 2010-05-05 EP disclosed
EP-1138712-B1 Polyarylene copolymers and proton-conductive membrane JSR CORP (JP) 2006-01-18 EP disclosed
US-6933068-B2 Polymer electrolyte membrane and solid polymer electrolyte fuel cell using same HONDA GIKEN KOGYO KABUSHIKI KAISHA (JP) 2005-08-23 US disclosed
US-6833426-B2 A proton-conductive membrane containing the sulfonic acid group-containing polyarylene (co)polymer JSR CORPORATION (JP) 2004-12-21 US disclosed
US-6812290-B2 FOR USE AS ELECTROLYTES JSR CORPORATION (JP) 2004-11-02 US disclosed
US-20030195301-A1 Polyarylene copolymers and proton-conductive membrane JSR CORPORATION (JP) 2003-10-16 US disclosed
US-20030173547-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORPORATION (JP) 2003-09-18 US disclosed
EP-1329444-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR Corporation (JP) 2003-07-23 EP disclosed
US-6555626-B2 Controlled amount of sulfonic acid groups; copolymer of an aromatic compound having a main chain containing electron withdrawing groups and aromatic compounds with no electron withdrawing groups; durability, strength, conductivity JSR CORPORATION (JP) 2003-04-29 US disclosed
US-20020172850-A1 Polymer electrolyte membrane and solid polymer electrolyte fuel cell using same HONDA GIKEN KOGYO KABUSHIKI KAISHA, JSR CORPORATION 2002-11-21 US disclosed
US-20010037000-A1 Polyarylene copolymers and proton-conductive membrane JSR CORPORATION (JP) 2001-11-01 US disclosed
EP-1138712-A2 Polyarylene copolymers and proton-conductive membrane JSR Corporation (JP) 2001-10-04 EP disclosed