Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.61 |
| ▸ | INSR | P06213 | 19/20 | 0.61 |
| ▸ | IGF1R | P08069 | 13/20 | 0.61 |
| ▸ | AURKA | O14965 | 4/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.61 |
| ▸ | PLK4 | O00444 | 2/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.58 |
| ▸ | PRKCG | P05129 | 2/20 | 0.58 |
| ▸ | ROS1 | P08922 | 2/20 | 0.58 |
| ▸ | FER | P16591 | 2/20 | 0.58 |
| ▸ | LTK | P29376 | 2/20 | 0.58 |
| ▸ | FRK | P42685 | 2/20 | 0.58 |
| ▸ | MST1R | Q04912 | 2/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.58 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.58 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.58 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.58 |
| ▸ | WEE1 | P30291 | 1/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3511890 | 0.97 | ALK (0.64) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL3510604 | 0.90 | NTRK1 (0.59) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL3680882 | 0.88 | ALK (0.54) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL3511728 | 0.85 | ALK (0.78) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL3512913 | 0.85 | ALK (0.77) | ALKINSRIGF1RAURKAAURKB | |
| Hydrochloric Acid SCHEMBL3513458 | 0.85 | ALK (0.76) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL3512806 | 0.83 | NTRK1 (0.57) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL3513791 | 0.82 | ALK (0.81) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL31391648 | 0.81 | NTRK1 (0.63) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL28999430 | 0.80 | ALK (0.59) | ALKINSRIGF1RAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176231-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009013126-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-01-29 | — | — | WO | disclosed |