Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 7/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL709786 | 0.89 | SCN9A (0.49) | SCN9ASCN3ASCN1AKCNH2SCN5A | |
| SCHEMBL710596 | 0.83 | SCN9A (0.59) | SCN9ASCN3ASCN1AKCNH2SCN5A | |
| SCHEMBL714098 | 0.82 | SCN9A (0.52) | SCN9ASCN3AKMT2AMEN1SCN1A | |
| SCHEMBL713543 | 0.81 | SCN9A (0.60) | SCN9ASCN3ALMNASMN1; SMN2MAPT | |
| SCHEMBL715219 | 0.80 | SCN9A (0.50) | SCN9ASCN3ASCN1ASCN5ASCN8A | |
| SCHEMBL710922 | 0.78 | SCN9A (0.55) | SCN9ASCN1ASCN8A | |
| SCHEMBL715212 | 0.76 | SCN9A (0.57) | SCN9ASCN3ASCN5A | |
| SCHEMBL711742 | 0.76 | SCN9A (0.51) | SCN9ASCN3ALMNASMN1; SMN2MAPT | |
| SCHEMBL710036 | 0.75 | SCN9A (0.72) | SCN9ASCN3ALMNASMN1; SMN2MAPT | |
| SCHEMBL714026 | 0.75 | SCN9A (0.53) | SCN9ASCN3AKMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173743-A2 | SODIUM CHANNEL INHIBITORS | Icagen, Inc. (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009012242-A2 | SODIUM CHANNEL INHIBITORS | ICAGEN, INC. (US) | 2009-01-22 | — | — | WO | disclosed |