Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 15/20 | 0.62 |
| ▸ | KDR | P35968 | 15/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 12/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 12/20 | 0.50 |
| ▸ | FLT3 | P36888 | 4/20 | 0.50 |
| ▸ | TTK | P33981 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16257036 | 0.78 | FGFR3 (0.72) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL3079717 | 0.77 | FGFR3 (0.60) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL2591038 | 0.77 | FGFR3 (0.71) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL29834960 | 0.77 | FGFR3 (0.71) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL12178582 | 0.77 | FGFR3 (0.71) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL12178238 | 0.77 | FGFR3 (0.71) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL3688517 | 0.77 | FGFR3 (0.63) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL3685812 | 0.75 | FGFR3 (0.55) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL3678302 | 0.75 | FGFR3 (0.60) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL24289863 | 0.74 | FGFR3 (0.67) | FGFR3KDRFGFR1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173354-A1 | QUINOXALINE DERIVATIVES AS PI3 KINASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009021083-A1 | QUINOXALINE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |