Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.71 |
| ▸ | CDK9 | P50750 | 7/20 | 0.71 |
| ▸ | CDK1 | P06493 | 15/20 | 0.70 |
| ▸ | CCNE1 | P24864 | 14/20 | 0.70 |
| ▸ | CDK4 | P11802 | 13/20 | 0.70 |
| ▸ | CDK7 | P50613 | 13/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 12/20 | 0.70 |
| ▸ | CCNH | P51946 | 12/20 | 0.70 |
| ▸ | CCNB1 | P14635 | 12/20 | 0.70 |
| ▸ | CCND1 | P24385 | 11/20 | 0.70 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.70 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.65 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.65 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.65 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.64 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.62 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.61 |
| ▸ | CLK2 | P49760 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5072601 | 0.88 | CDK2 (0.81) | CDK2CDK9CDK1CCNE1CDK4 | |
| SCHEMBL3681786 | 0.85 | CDK2 (0.72) | CDK2CDK9CDK1CCNE1CDK4 | |
| SCHEMBL3300735 | 0.83 | CDK2 (1.00) | CDK2CDK9CDK1CCNE1CDK4 | |
| SCHEMBL3300752 | 0.83 | CDK2 (1.00) | CDK2CDK9CDK1CCNE1CDK4 | |
| SCHEMBL3305160 | 0.83 | CDK2 (0.75) | CDK2CDK9CDK1CCNE1CDK4 | |
| SCHEMBL1376524 | 0.82 | CDK2 (1.00) | CDK2CDK9CDK1CCNE1CDK4 | |
| SCHEMBL1374946 | 0.82 | CDK2 (1.00) | CDK2CDK9CDK1CCNE1CDK4 | |
| SCHEMBL1379209 | 0.82 | CDK2 (1.00) | CDK2CDK9CDK1CCNE1CDK4 | |
| SCHEMBL3300432 | 0.81 | CDK2 (1.00) | CDK2CDK9CDK1CCNE1CDK4 | |
| SCHEMBL14396823 | 0.81 | CDK2 (0.81) | CDK2CDK9CDK1CCNE1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139486-A1 | COMBINATION OF A PURINE-BASED CDK INHIBITOR WITH A TYROSINE KINASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF PROLIFERATIVE DISORDERS | Cyclacel Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008122779-A1 | COMBINATION OF A PURINE-BASED CDK INHIBITOR WITH A TYROSINE KINASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF PROLIFERATIVE DISORDERS | CYCLACEL LIMITED (GB) | 2008-10-16 | — | — | WO | disclosed |