Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 20/20 | 0.52 |
| ▸ | PTGER3 | P43115 | 10/20 | 0.51 |
| ▸ | PTGER2 | P43116 | 7/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3674143 | 0.86 | PTGER4 (0.70) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL3674145 | 0.86 | PTGER4 (0.70) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL3674182 | 0.84 | PTGER4 (0.58) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL3674186 | 0.84 | PTGER4 (0.58) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL3675239 | 0.83 | PTGER4 (0.61) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL2209048 | 0.80 | PTGER4 (0.62) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL2210072 | 0.80 | PTGER4 (0.62) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL2210082 | 0.80 | PTGER4 (0.62) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL2209058 | 0.80 | PTGER4 (0.62) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL2211071 | 0.79 | PTGER4 (0.45) | PTGER4PTGER3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513589-B1 | 1,5-DISUBSTITUTED PYRROLID-2-ONE DERIVATIVES FOR USE AS EP4 RECEPTOR AGONISTS IN THE TREATMENT OF EYE DISEASES SUCH AS GLAUCOMA | MERCK FROSST CANADA LTD (CA) | 2010-11-10 | — | — | EP | claimed |