Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 16/20 | 0.81 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.81 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.81 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.81 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.81 |
| ▸ | PRKDC | P78527 | 3/20 | 0.81 |
| ▸ | ATM | Q13315 | 3/20 | 0.81 |
| ▸ | PIK3C2A | O00443 | 2/20 | 0.81 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.81 |
| ▸ | ATR | Q13535 | 2/20 | 0.81 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.81 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.81 |
| ▸ | CSF1R | P07333 | 1/20 | 0.81 |
| ▸ | MET | P08581 | 1/20 | 0.81 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.81 |
| ▸ | LTK | P29376 | 1/20 | 0.81 |
| ▸ | CDK7 | P50613 | 1/20 | 0.81 |
| ▸ | NEK2 | P51955 | 1/20 | 0.81 |
| ▸ | JAK3 | P52333 | 1/20 | 0.81 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dactolisib SCHEMBL30186162 | 0.90 | MTOR (1.00) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| Dactolisib SCHEMBL2424463 | 0.90 | MTOR (1.00) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| Dactolisib SCHEMBL29370906 | 0.90 | MTOR (1.00) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| Dactolisib SCHEMBL143623 | 0.90 | MTOR (1.00) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL928053 | 0.86 | PIK3CA (0.61) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL15747813 | 0.85 | MTOR (0.89) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL927324 | 0.84 | MTOR (0.82) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL9277667 | 0.84 | MTOR (0.81) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL9905064 | 0.83 | MTOR (0.66) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL928021 | 0.83 | MTOR (0.87) | MTORPIK3CAPIK3CDPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3024456-A1 | COMBINATORIAL METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF BISANTRENE | Update Pharma Inc. (US) | 2016-06-01 | — | — | EP | disclosed |
| EP-3024457-A1 | COMPOSITIONS TO IMPROVE THE THERAPEUTIC BENEFIT OF BISANTRENE | Update Pharma Inc. (US) | 2016-06-01 | — | — | EP | disclosed |
| WO-2015013579-A1 | COMPOSITIONS TO IMPROVE THE THERAPEUTIC BENEFIT OF BISANTRENE | UPDATE PHARMA INC. (US) | 2015-01-29 | — | — | WO | disclosed |
| WO-2015013581-A1 | COMBINATORIAL METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF BISANTRENE | UPDATE PHARMA INC. (US) | 2015-01-29 | — | — | WO | disclosed |
| EP-2182948-A1 | USE OF IMIDAZOQUINOLINES FOR THE TREATMENT OF EGFR DEPENDENT DISEASES OR DISEASES THAT HAVE ACQUIRED RESISTANCE TO AGENTS THAT TARGET EGFR FAMILY MEMBERS | Novartis Ag (CH) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009013305-A1 | USE OF IMIDAZOQUINOLINES FOR THE TREATMENT OF EGFR DEPENDENT DISEASES OR DISEASES THAT HAVE ACQUIRED RESISTANCE TO AGENTS THAT TARGET EGFR FAMILY MEMBERS | NOVARTIS AG (CH) | 2009-01-29 | — | — | WO | disclosed |