Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 20/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3683944 | 0.89 | MAP2K1 (0.75) | MAP2K1 | |
| SCHEMBL3688364 | 0.88 | MAP2K1 (0.81) | MAP2K1 | |
| SCHEMBL3685815 | 0.88 | MAP2K1 (0.81) | MAP2K1 | |
| SCHEMBL3692524 | 0.88 | MAP2K1 (0.84) | MAP2K1 | |
| SCHEMBL3807450 | 0.88 | MAP2K1 (0.73) | MAP2K1 | |
| SCHEMBL3686205 | 0.87 | MAP2K1 (0.75) | MAP2K1 | |
| SCHEMBL3692231 | 0.86 | MAP2K1 (0.79) | MAP2K1 | |
| SCHEMBL13046768 | 0.86 | MAP2K1 (0.81) | MAP2K1 | |
| SCHEMBL3690007 | 0.86 | MAP2K1 (0.78) | MAP2K1 | |
| SCHEMBL3688745 | 0.85 | MAP2K1 (0.74) | MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578351-B1 | PYRROLOPYRIDAZINE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | BRISTOL MYERS SQUIBB CO (US) | 2010-12-08 | — | — | EP | disclosed |
| EP-1578351-B1 | PYRROLOPYRIDAZINE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | BRISTOL MYERS SQUIBB CO (US) | 2010-12-08 | — | — | EP | disclosed |
| US-7030112-B2 | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-04-18 | — | — | US | disclosed |
| US-6900208-B2 | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders | BRISTOL MYERS SQUIBB COMPANY (US) | 2005-05-31 | — | — | US | disclosed |