Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPP1CA | P62136 | 3/20 | 0.83 |
| ▸ | RPA1 | P27694 | 12/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | MARS1 | P56192 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1764957 | 0.90 | PPP1CA (0.75) | PPP1CARPA1L3MBTL1MARS1SMN1; SMN2 | |
| SCHEMBL1765063 | 0.89 | PPP1CA (0.82) | PPP1CARPA1L3MBTL1MARS1SMN1; SMN2 | |
| SCHEMBL1514559 | 0.88 | PPP1CA (1.00) | PPP1CARPA1L3MBTL1MARS1SMN1; SMN2 | |
| SCHEMBL1514562 | 0.87 | RPA1 (0.85) | PPP1CARPA1L3MBTL1MARS1SMN1; SMN2 | |
| SCHEMBL1110855 | 0.87 | PPP1CA (0.87) | PPP1CARPA1L3MBTL1MARS1SMN1; SMN2 | |
| SCHEMBL1765058 | 0.86 | PPP1CA (0.77) | PPP1CARPA1L3MBTL1MARS1SMN1; SMN2 | |
| SCHEMBL20785644 | 0.85 | PPP1CA (0.68) | PPP1CARPA1L3MBTL1MARS1SMN1; SMN2 | |
| SCHEMBL1765444 | 0.83 | PPP1CA (0.72) | PPP1CARPA1L3MBTL1MARS1SMN1; SMN2 | |
| SCHEMBL14995361 | 0.82 | PPP1CA (0.71) | PPP1CARPA1L3MBTL1MARS1SMN1; SMN2 | |
| SCHEMBL1765593 | 0.82 | PPP1CA (0.71) | PPP1CARPA1L3MBTL1MARS1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167472-A2 | 1-BENZYLPYRAZOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-03-31 | — | — | EP | disclosed |
| WO-2009004171-A2 | 1-BENZYLPYRAZOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-01-08 | — | — | WO | disclosed |