SCHEMBL3684726

SCHEMBL3684726

[CH2]c1ccc(C#N)cc1CC(c1cnc[nH]1)N1CC(=O)N(c2cccc(C)c2C)C[C@@H]1CCCC

nearest known ligand 0.51

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FNTA P49354 12/20 0.51
FNTB P49356 11/20 0.51
PGGT1B P53609 2/20 0.51
GRM2 Q14416 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL445626 0.89 FNTA (0.59) FNTAFNTBPGGT1BGRM2
SCHEMBL3687066 0.89 FNTA (0.59) FNTAFNTBPGGT1BGRM2
Trifluoroacetic Acid SCHEMBL8147178 0.84 FNTA (0.54) FNTAFNTBPGGT1B
SCHEMBL445939 0.83 FNTA (0.51) FNTAFNTBPGGT1BGRM2
SCHEMBL5131468 0.83 FNTA (0.51) FNTAFNTBPGGT1BGRM2
Hydrochloric Acid SCHEMBL8541088 0.83 FNTA (0.51) FNTAFNTBPGGT1BGRM2
Hydrochloric Acid SCHEMBL8160943 0.83 FNTA (0.51) FNTAFNTBPGGT1BGRM2
SCHEMBL3499540 0.80 FNTA (0.48) FNTAFNTBPGGT1B
SCHEMBL3682663 0.80 FNTA (0.48) FNTAFNTBPGGT1B
SCHEMBL3501112 0.79 FNTA (0.56) FNTAFNTBPGGT1BGRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010057028-A9 TREATMENT OF PROTEINOPATHIES USING A FARNESYL TRANSFERASE INHIBITOR LINK MEDICINE CORPORATION (US) 2010-09-02 WO disclosed