Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 18/20 | 0.63 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.54 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.42 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3757287 | 0.96 | IGF1R (0.63) | IGF1RMAPK8MAPK10INSRALK | |
| SCHEMBL3692911 | 0.90 | IGF1R (0.63) | IGF1RMAPK8MAPK10INSRALK | |
| SCHEMBL3694899 | 0.88 | IGF1R (0.62) | IGF1RMAPK8MAPK10INSRALK | |
| SCHEMBL3801205 | 0.88 | IGF1R (0.60) | IGF1RMAPK8MAPK10INSRALK | |
| SCHEMBL3683708 | 0.87 | IGF1R (0.62) | IGF1RMAPK8MAPK10INSRALK | |
| SCHEMBL3264215 | 0.86 | IGF1R (0.48) | IGF1RMAPK8MAPK10INSRALK | |
| SCHEMBL3684594 | 0.85 | IGF1R (0.54) | IGF1RMAPK8MAPK10INSRALK | |
| SCHEMBL3692551 | 0.82 | IGF1R (0.53) | IGF1RMAPK8MAPK10INSRALK | |
| SCHEMBL3687691 | 0.82 | IGF1R (0.62) | IGF1RMAPK8MAPK10INSRALK | |
| SCHEMBL3752592 | 0.82 | IGF1R (0.51) | IGF1RMAPK8MAPK10INSRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188292-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D]PYRIMIDIN-4-YL) AMINO]BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009020990-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D] PYRIMIDIN-4-YL) AMINO] BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |