Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | NT5E | P21589 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | STAT3 | P40763 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SCD | O00767 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5749796 | 0.96 | KDM4E (0.63) | KDM4EL3MBTL1NT5EKMT2AGAA | |
| SCHEMBL5751597 | 0.94 | KDM4E (0.61) | KDM4EL3MBTL1NT5EKMT2AGAA | |
| SCHEMBL1553020 | 0.91 | KDM4E (0.69) | KDM4EL3MBTL1NT5EKMT2AGAA | |
| Hydrochloric Acid SCHEMBL1396788 | 0.90 | KDM4E (0.67) | KDM4EL3MBTL1NT5EKMT2AGAA | |
| SCHEMBL24670336 | 0.86 | TRPV1 (0.57) | KDM4EKMT2APOLBSMN1; SMN2TRPV1 | |
| SCHEMBL31610762 | 0.85 | TRPV1 (0.74) | KDM4EL3MBTL1NT5EKMT2ASTAT3 | |
| SCHEMBL23291297 | 0.85 | GAA (0.69) | KDM4EL3MBTL1NT5EKMT2AGAA | |
| SCHEMBL1438598 | 0.84 | KDM4E (0.73) | KDM4EL3MBTL1NT5EKMT2AGAA | |
| SCHEMBL5754890 | 0.83 | KDM4E (0.71) | KDM4EL3MBTL1NT5EKMT2AGAA | |
| Hydrochloric Acid SCHEMBL5462828 | 0.83 | KDM4E (0.71) | KDM4EL3MBTL1NT5EKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1715862-A1 | KINASE INHIBITORS | Devgen NV (BE) | 2006-11-02 | — | — | EP | claimed |
| WO-2005082367-A1 | KINASE INHIBITORS | DEVGEN NV (BE) | 2005-09-09 | — | — | WO | claimed |
| WO-2010049173-A1 | USE OF INHIBITORS OF HOST KINASES FOR THE TREATMENT OF INFECTIOUS DISEASES | CENIX BIOSCIENCE GMBH (DE) | 2010-05-06 | — | — | WO | disclosed |