Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.48 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.41 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1303033 | 0.90 | EGLN1 (0.46) | EGLN1PIK3CGMAP3K5PIK3CAPIK3CD | |
| SCHEMBL1303473 | 0.88 | MAP3K5 (0.48) | EGLN1PIK3CGALDH1A3MAP3K5PIK3CA | |
| SCHEMBL1302407 | 0.85 | MAP3K5 (0.44) | EGLN1PIK3CGMAP3K5PIK3CAPIK3CD | |
| SCHEMBL1302756 | 0.85 | PIK3CA (0.42) | PIK3CGMAP3K5PIK3CAPIK3CD | |
| SCHEMBL1303642 | 0.85 | MAP3K5 (0.52) | PIK3CGMAP3K5PIK3CA | |
| SCHEMBL1302482 | 0.84 | CLK2 (0.47) | EGLN1PIK3CGMAP3K5PIK3CAPIK3CD | |
| SCHEMBL1304051 | 0.84 | PIK3CA (0.46) | PIK3CGMAP3K5PIK3CAPIK3CD | |
| SCHEMBL1302775 | 0.83 | MAP3K5 (0.40) | PIK3CGMAP3K5PIK3CAPIK3CD | |
| SCHEMBL1303623 | 0.82 | PIK3CA (0.39) | PIK3CGMAP3K5PIK3CAPIK3CD | |
| SCHEMBL1303382 | 0.82 | PIK3CA (0.40) | PIK3CGMAP3K5PIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178868-A1 | BICYCLIC HETEROARYL COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Novartis Ag (CH) | 2010-04-28 | — | — | EP | claimed |
| WO-2009010530-A1 | BICYCLIC HETEROARYL COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-01-22 | — | — | WO | claimed |