Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 5/20 | 0.53 |
| ▸ | PI4KA | P42356 | 2/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.51 |
| ▸ | MTOR | P42345 | 6/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.49 |
| ▸ | PRKDC | P78527 | 2/20 | 0.49 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.49 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.49 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.49 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.49 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.49 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.49 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL368716 | 1.00 | PIK3CG (0.53) | PIK3CGPI4KAPIK3CAPIK3R1MTOR | |
| SCHEMBL368101 | 0.90 | PIK3CA (0.54) | PIK3CGPI4KAPIK3CAPIK3R1MTOR | |
| SCHEMBL369458 | 0.90 | PIK3CA (0.54) | PIK3CGPI4KAPIK3CAPIK3R1MTOR | |
| SCHEMBL367906 | 0.89 | PIK3CG (0.54) | PIK3CGPI4KAPIK3CAPIK3R1MTOR | |
| SCHEMBL367861 | 0.89 | PIK3CG (0.54) | PIK3CGPI4KAPIK3CAPIK3R1MTOR | |
| SCHEMBL367692 | 0.82 | PIK3CG (0.52) | PIK3CGPI4KAPIK3CAPIK3R1MTOR | |
| SCHEMBL14913991 | 0.82 | PIK3CG (0.52) | PIK3CGPI4KAPIK3CAPIK3R1MTOR | |
| SCHEMBL367189 | 0.82 | PIK3CD (0.51) | PIK3CGPI4KAPIK3CAPIK3R1MTOR | |
| SCHEMBL368220 | 0.82 | PIK3CA (0.56) | PIK3CGPIK3CAPIK3R1MTORPIK3CD | |
| SCHEMBL14914937 | 0.82 | PIK3CA (0.56) | PIK3CGPIK3CAPIK3R1MTORPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9062046-B2 | Substituted imidazoquinoline derivatives as kinase inhibitors | Piramal Enterprises Limited (IN) | 2015-06-23 | — | — | US | claimed |
| US-20130116248-A1 | SUBSTITUTED IMIDAZOQUINOLINE DERIVATIVES AS KINASE INHIBITORS | Piramal Enterprises Limited (IN) | 2013-05-09 | — | — | US | claimed |
| US-9062046-B2 | Substituted imidazoquinoline derivatives as kinase inhibitors | Piramal Enterprises Limited (IN) | 2015-06-23 | — | — | US | disclosed |
| EP-2593450-A1 | SUBSTITUTED IMIDAZOQUINOLINE DERIVATIVES AS KINASE INHIBITORS | Piramal Enterprises Limited (IN) | 2013-05-22 | — | — | EP | disclosed |
| US-20130116248-A1 | SUBSTITUTED IMIDAZOQUINOLINE DERIVATIVES AS KINASE INHIBITORS | Piramal Enterprises Limited (IN) | 2013-05-09 | — | — | US | disclosed |
| WO-2012007926-A1 | SUBSTITUTED IMIDAZOQUINOLINE DERIVATIVES AS KINASE INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116248-A1 | SUBSTITUTED IMIDAZOQUINOLINE DERIVATIVES AS KINASE INHIBITORS | CDK2, CDK4, MAP3K1 | PIK3CG 139/4885PI4KA 91/4885PIK3CA 72/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.