Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 6/20 | 0.44 |
| ▸ | ACHE | P22303 | 5/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3685871 | 0.87 | PTPN1 (0.45) | MAPTNPC1RAB9AKMT2ABCHE | |
| SCHEMBL3686241 | 0.87 | PTPN1 (0.45) | MAPTNPC1RAB9AKMT2ABCHE | |
| SCHEMBL3691225 | 0.84 | MAPT (0.38) | MAPTSMN1; SMN2KMT2ABCHEACHE | |
| SCHEMBL3696585 | 0.84 | MAPT (0.38) | MAPTSMN1; SMN2KMT2ABCHEACHE | |
| SCHEMBL3685711 | 0.84 | BCHE (0.58) | MAPTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL5915789 | 0.83 | MAOB (0.44) | MAPTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL5915673 | 0.83 | MAOB (0.44) | MAPTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL5915682 | 0.82 | BCHE (0.43) | MAPTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL5915546 | 0.82 | BCHE (0.43) | MAPTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL5915402 | 0.82 | MAPT (0.59) | MAPTSMN1; SMN2NPC1KMT2ACYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | claimed |
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |