Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.51 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.46 |
| ▸ | INSR | P06213 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3805166 | 0.95 | IGF1R (0.57) | IGF1RCAMK2DALKINSRMAPK10 | |
| SCHEMBL3695065 | 0.94 | IGF1R (0.48) | IGF1RCAMK2DALKINSRMAPK10 | |
| SCHEMBL3692916 | 0.89 | IGF1R (0.62) | IGF1RCAMK2DALKINSRMAPK10 | |
| SCHEMBL3757450 | 0.87 | ZAP70 (0.52) | IGF1RCAMK2DALKINSRMAPK10 | |
| SCHEMBL3266025 | 0.86 | IGF1R (0.53) | IGF1RCAMK2DALKINSRFGFR1 | |
| SCHEMBL3693459 | 0.86 | IGF1R (0.49) | IGF1RCAMK2DALKINSRMAPK10 | |
| SCHEMBL3686747 | 0.85 | IGF1R (0.63) | IGF1RALKINSRMAPK10MAPK8 | |
| SCHEMBL3697393 | 0.85 | MAPK10 (0.62) | IGF1RCAMK2DALKINSRMAPK10 | |
| SCHEMBL3764902 | 0.85 | IGF1R (0.44) | IGF1RMAPK10MAPK9MAPK8PTK2 | |
| SCHEMBL3760890 | 0.84 | IGF1R (0.51) | IGF1RALKINSRMAPK10MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188292-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D]PYRIMIDIN-4-YL) AMINO]BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009020990-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D] PYRIMIDIN-4-YL) AMINO] BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |