Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.38 |
| ▸ | CDK9 | P50750 | 6/20 | 0.38 |
| ▸ | GRK2 | P25098 | 1/20 | 0.38 |
| ▸ | GRK5 | P34947 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3695916 | 0.96 | IGF1R (0.60) | IGF1RAURKBMAPK8INSRALK | |
| SCHEMBL3685794 | 0.91 | IGF1R (0.66) | IGF1RAURKBMAPK8INSRALK | |
| SCHEMBL3690895 | 0.89 | IGF1R (0.56) | IGF1RAURKBMAPK8INSRALK | |
| SCHEMBL3687871 | 0.89 | IGF1R (0.55) | IGF1RAURKBMAPK8INSRALK | |
| SCHEMBL3689329 | 0.89 | IGF1R (0.55) | IGF1RAURKBMAPK8INSRALK | |
| SCHEMBL3692560 | 0.89 | IGF1R (0.55) | IGF1RAURKBMAPK8INSRALK | |
| SCHEMBL3760948 | 0.88 | IGF1R (0.64) | IGF1RAURKBMAPK8INSRALK | |
| SCHEMBL3757215 | 0.87 | IGF1R (0.48) | IGF1RAURKBMAPK8INSRALK | |
| SCHEMBL3761417 | 0.86 | IGF1R (0.57) | IGF1RAURKBMAPK8INSRALK | |
| SCHEMBL3757299 | 0.86 | IGF1R (0.52) | IGF1RAURKBMAPK8INSRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188292-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D]PYRIMIDIN-4-YL) AMINO]BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009020990-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D] PYRIMIDIN-4-YL) AMINO] BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |