⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL321521 | 0.79 | — | — | |
| SCHEMBL1137481 | 0.79 | MEN1 (0.33) | — | |
| Hydrochloric Acid SCHEMBL5269910 | 0.77 | MEN1 (0.32) | — | |
| Water SCHEMBL31456290 | 0.77 | MEN1 (0.32) | — | |
| SCHEMBL787268 | 0.74 | MEN1 (0.32) | — | |
| SCHEMBL370515 | 0.74 | — | — | |
| SCHEMBL7939314 | 0.74 | — | — | |
| SCHEMBL19330081 | 0.74 | — | — | |
| SCHEMBL12464312 | 0.74 | MEN1 (0.32) | — | |
| SCHEMBL10582934 | 0.74 | MEN1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802650-B1 | 3-ETHER AND 3-THIOETHER SUBSTITUTED CYCLOSPORIN DERIVATIVES FOR THE TREATMENT AND PREVENTION OF HEPATITIS C INFECTION | SCYNEXIS INC (US) | 2011-10-26 | — | — | EP | claimed |
| EP-1802650-A4 | 3-ETHER AND 3-THIOETHER SUBSTITUTED CYCLOSPORIN DERIVATIVES FOR THE TREATMENT AND PREVENTION OF HEPATITIS C INFECTION | SCYNEXIS INC (US) | 2008-08-20 | — | — | EP | claimed |
| EP-1802650-A2 | 3-ETHER AND 3-THIOETHER SUBSTITUTED CYCLOSPORIN DERIVATIVES FOR THE TREATMENT AND PREVENTION OF HEPATITIS C INFECTION | Scynexis, Inc. (US) | 2007-07-04 | — | — | EP | claimed |
| US-20060160727-A1 | 3-Ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection | FLIRI HANS G | 2006-07-20 | — | — | US | claimed |
| US-20060089301-A1 | 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection | SCYNEXIS, INC. | 2006-04-27 | — | — | US | claimed |
| WO-2006039668-A2 | 3-ETHER AND 3-THIOETHER SUBSTITUTED CYCLOSPORIN DERIVATIVES FOR THE TREATMENT AND PREVENTION OF HEPATITIS C INFECTION | SCYNEXIS, INC (US) | 2006-04-13 | — | — | WO | claimed |
| JP-3193379-B2 | — | — | 2001-07-30 | — | — | JP | claimed |
| EP-0626943-B1 | BISTRIAZENES AS CHEMOTHERAPEUTIC AGENTS | US HEALTH (US) | 2000-01-26 | — | — | EP | claimed |
| US-5808038-A | ANTICARCER AGENT | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1998-09-15 | — | — | US | claimed |
| EP-0626943-A1 | BISTRIAZENES AS CHEMOTHERAPEUTIC AGENTS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1994-12-07 | — | — | EP | claimed |
| WO-1993009089-A1 | BISTRIAZENES AS CHEMOTHERAPEUTIC AGENTS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1993-05-13 | — | — | WO | claimed |
| US-4980356-A | ANTICONVULSANTS; ANTISPASMODIC AGENTS; MUSCULAR AND NERVOUS SYSTEMS DISORDERS | RHONE-POULENC SANTE (FR) | 1990-12-25 | — | — | US | claimed |
| CN-118324867-A | Novel cyclosporin derivatives and uses thereof | 美国科技环球有限公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-109476705-B | Novel cyclosporin derivatives and uses thereof | 美国科技环球有限公司 | 2024-02-27 | — | — | CN | disclosed |
| EP-3831841-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T Global Inc. (US) | 2021-06-09 | — | — | EP | disclosed |
| US-10647747-B2 | Cyclosporin derivatives and uses thereof | S&T GLOBAL INC. (US) | 2020-05-12 | — | — | US | disclosed |
| US-5026717-A | Glutamate inhibitors | RHONE-POULENC SANTE (FR) | 1991-06-25 | — | — | US | disclosed |
| US-5026717-A | Glutamate inhibitors | RHONE-POULENC SANTE (FR) | 1991-06-25 | — | — | US | disclosed |
| US-4980356-A | ANTICONVULSANTS; ANTISPASMODIC AGENTS; MUSCULAR AND NERVOUS SYSTEMS DISORDERS | RHONE-POULENC SANTE (FR) | 1990-12-25 | — | — | US | disclosed |
| US-4980356-A | ANTICONVULSANTS; ANTISPASMODIC AGENTS; MUSCULAR AND NERVOUS SYSTEMS DISORDERS | RHONE-POULENC SANTE (FR) | 1990-12-25 | — | — | US | disclosed |