Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 17/20 | 0.44 |
| ▸ | RAB9A | P51151 | 16/20 | 0.44 |
| ▸ | MEN1 | O00255 | 13/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.44 |
| ▸ | RELA | Q04206 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MECP2 | P51608 | 1/20 | 0.43 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.43 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.43 |
| ▸ | MBD2 | Q9UBB5 | 1/20 | 0.43 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370589 | 0.90 | NPC1 (0.54) | GRM4NPC1RAB9AMEN1KMT2A | |
| SCHEMBL12482377 | 0.89 | GRM4 (0.52) | GRM4NPC1RAB9AMEN1KMT2A | |
| SCHEMBL370842 | 0.88 | GRM4 (0.55) | GRM4NPC1RAB9AMEN1KMT2A | |
| SCHEMBL370539 | 0.79 | GRM4 (0.58) | GRM4NPC1RAB9AMEN1KMT2A | |
| SCHEMBL370213 | 0.76 | GRM4 (0.54) | GRM4NPC1RAB9AMEN1KMT2A | |
| SCHEMBL2512028 | 0.74 | GRM4 (0.54) | GRM4NPC1RAB9AMEN1KMT2A | |
| SCHEMBL2531955 | 0.73 | GRM4 (0.53) | GRM4NPC1RAB9AMEN1KMT2A | |
| SCHEMBL370860 | 0.73 | GRM4 (0.64) | GRM4NPC1RAB9AMEN1KMT2A | |
| SCHEMBL370631 | 0.72 | NPC1 (0.68) | GRM4NPC1RAB9AMEN1KMT2A | |
| SCHEMBL371001 | 0.71 | NPC1 (0.61) | GRM4NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595986-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-29 | — | — | EP | claimed |
| WO-2012009009-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | claimed |
| EP-2595986-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012009009-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | disclosed |