Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 6/20 | 0.57 |
| ▸ | KCNQ2 | O43526 | 6/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3696279 | 0.90 | KCNQ3 (0.52) | KCNQ3KCNQ2SMN1; SMN2LMNAHPGD | |
| SCHEMBL3706860 | 0.90 | MAPK14 (0.56) | KCNQ3KCNQ2PTGS2MAPK14SMN1; SMN2 | |
| SCHEMBL3703621 | 0.89 | KCNQ3 (0.58) | KCNQ3KCNQ2PTGS2MAPK14SMN1; SMN2 | |
| SCHEMBL3698911 | 0.85 | KCNQ3 (0.56) | KCNQ3KCNQ2PTGS2MAPK14SMN1; SMN2 | |
| SCHEMBL3706797 | 0.85 | KCNQ3 (0.51) | KCNQ3KCNQ2SMN1; SMN2MAPTLMNA | |
| SCHEMBL3708663 | 0.82 | KCNQ2 (0.52) | KCNQ3KCNQ2PTGS2MAPK14RAB9A | |
| SCHEMBL3704649 | 0.78 | KCNQ3 (0.50) | KCNQ3KCNQ2SMN1; SMN2MAPTLMNA | |
| SCHEMBL3698052 | 0.76 | KCNQ3 (0.61) | KCNQ3KCNQ2MAPK14WNT3A | |
| SCHEMBL3710537 | 0.75 | PDE2A (0.46) | KCNQ3KCNQ2SMN1; SMN2LMNAHTT | |
| SCHEMBL3701916 | 0.74 | MAPK14 (0.52) | KCNQ3KCNQ2PTGS2MAPK14SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609669-B2 | Potassium channel modulators | ABBVIE INC. (US) | 2013-12-17 | — | — | US | claimed |
| WO-2012067822-A1 | PYRAZOLO [1, 5 -A] PYRIMIDIN POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-05-24 | — | — | WO | claimed |
| US-20120122888-A1 | Potassium Channel Modulators | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | claimed |
| US-8609669-B2 | Potassium channel modulators | ABBVIE INC. (US) | 2013-12-17 | — | — | US | disclosed |
| WO-2012067822-A1 | PYRAZOLO [1, 5 -A] PYRIMIDIN POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-05-24 | — | — | WO | disclosed |
| US-20120122888-A1 | Potassium Channel Modulators | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122888-A1 | Potassium Channel Modulators | KCNQ1, KCNQ2, KCNJ2 | KCNQ3 4/4885KCNQ2 2/4885PTGS2 1276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.