Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.50 |
| ▸ | MTOR | P42345 | 3/20 | 0.49 |
| ▸ | ATR | Q13535 | 2/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12267760 | 0.89 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL2396343 | 0.88 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL13349747 | 0.88 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL2398761 | 0.88 | PIK3CD (0.46) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL2394451 | 0.88 | PIK3CA (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL2394633 | 0.87 | PIK3CA (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL1949817 | 0.86 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL2396961 | 0.86 | PIK3CA (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL13885983 | 0.85 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL2395806 | 0.85 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215090-A1 | PURINE DERIVATIVES USEFUL AS PI3 KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-08-11 | — | — | EP | claimed |
| WO-2009053716-A1 | PURINE DERIVATIVES USEFUL AS PI3 KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | claimed |