Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 11/20 | 0.67 |
| ▸ | GRM8 | O00222 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369775 | 0.91 | GRM4 (0.69) | GRM4GRM8KCNH2KDRAURKB | |
| SCHEMBL367310 | 0.89 | GRM4 (0.72) | GRM4GRM8KCNH2KDRADORA3 | |
| SCHEMBL369152 | 0.81 | GRM4 (1.00) | GRM4GRM8KCNH2KDRALDH1A1 | |
| SCHEMBL370275 | 0.80 | GRM4 (0.73) | GRM4GRM8KCNH2KDRALDH1A1 | |
| SCHEMBL15166674 | 0.80 | GRM4 (0.53) | GRM4GRM8KCNH2KDRADORA3 | |
| SCHEMBL369427 | 0.80 | GRM4 (0.72) | GRM4GRM8KCNH2KDRADORA3 | |
| SCHEMBL368114 | 0.80 | GRM4 (0.53) | GRM4GRM8KCNH2AURKB | |
| SCHEMBL12482364 | 0.79 | GRM4 (0.53) | GRM4GRM8KCNH2KDRADORA3 | |
| SCHEMBL369761 | 0.78 | GRM4 (0.70) | GRM4GRM8KCNH2KDRALDH1A1 | |
| SCHEMBL365856 | 0.78 | GRM4 (0.69) | GRM4GRM8KCNH2KDRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595986-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-29 | — | — | EP | claimed |
| WO-2012009009-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | claimed |