Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 11/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369956 | 1.00 | SCN9A (0.48) | SCN9ARAB9AMAPK1S1PR1S1PR3 | |
| SCHEMBL365394 | 0.81 | S1PR1 (0.41) | SCN9ARAB9AMAPK1S1PR1S1PR3 | |
| SCHEMBL10198424 | 0.81 | S1PR1 (0.41) | SCN9ARAB9AMAPK1S1PR1S1PR3 | |
| SCHEMBL364997 | 0.81 | S1PR1 (0.41) | SCN9ARAB9AMAPK1S1PR1S1PR3 | |
| SCHEMBL16240182 | 0.80 | SCN9A (0.45) | SCN9ARAB9AMAPK1MRGPRX4MEN1 | |
| SCHEMBL16175138 | 0.75 | MAPK1 (0.40) | SCN9ARAB9AMAPK1MEN1KMT2A | |
| SCHEMBL364199 | 0.75 | SCN9A (0.41) | SCN9ARAB9AMAPK1S1PR1S1PR3 | |
| SCHEMBL370604 | 0.75 | AAK1 (0.43) | SCN9AS1PR1S1PR3S1PR5 | |
| SCHEMBL370605 | 0.75 | AAK1 (0.43) | SCN9AS1PR1S1PR3S1PR5 | |
| SCHEMBL16175571 | 0.74 | MAPK1 (0.37) | SCN9ARAB9AMAPK1MRGPRX4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593432-A1 | N-SULFONYLBENZAMIDE DERIVATIVES USEFUL AS VOLTAGE GATED SODIUM CHANNEL INHIBITORS | Pfizer Limited (GB) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007861-A1 | N-SULFONYLBENZAMIDE DERIVATIVES USEFUL AS VOLTAGE GATED SODIUM CHANNEL INHIBITORS | PFIZER LIMITED (GB) | 2012-01-19 | — | — | WO | disclosed |