Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.72 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.72 |
| ▸ | PTK2 | Q05397 | 12/20 | 0.64 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.63 |
| ▸ | KIT | P10721 | 2/20 | 0.62 |
| ▸ | JAK3 | P52333 | 2/20 | 0.58 |
| ▸ | GSK3A | P49840 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1916486 | 0.94 | CHEK1 (0.83) | FLT3CHEK1PTK2STK17AKIT | |
| SCHEMBL3283901 | 0.89 | FLT3 (0.70) | FLT3CHEK1PTK2STK17AKIT | |
| SCHEMBL3283599 | 0.87 | FLT3 (0.70) | FLT3CHEK1PTK2STK17AKIT | |
| SCHEMBL1916813 | 0.86 | PTK2 (0.70) | FLT3CHEK1PTK2 | |
| SCHEMBL3285524 | 0.86 | FLT3 (0.71) | FLT3CHEK1PTK2STK17AKIT | |
| SCHEMBL1917534 | 0.85 | FLT3 (0.64) | FLT3CHEK1PTK2KIT | |
| SCHEMBL3284837 | 0.85 | PTK2 (0.62) | FLT3CHEK1PTK2KITJAK3 | |
| SCHEMBL28242860 | 0.84 | FLT3 (0.75) | FLT3CHEK1PTK2KITJAK3 | |
| SCHEMBL3290067 | 0.83 | FLT3 (0.62) | FLT3CHEK1PTK2KIT | |
| SCHEMBL1916456 | 0.83 | CHEK1 (0.62) | FLT3CHEK1PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090571-B1 | Pyrimidine derivates, medicaments comprising them, their use and process of their preparation | BOEHRINGER INGELHEIM PHARMA (DE) | 2012-05-16 | — | — | EP | disclosed |
| EP-2090571-A1 | Pyrimidine derivates, medicaments comprising them, their use and process of their preparation | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-1438053-B1 | PYRIMIDINE DERIVATIVES, PHARMACEUTICAL AGENT CONTAINING SAID COMPOUNDS, USE AND METHOD FOR MAKING SAME | BOEHRINGER INGELHEIM PHARMA (DE) | 2008-09-10 | — | — | EP | disclosed |
| EP-1438053-A1 | PYRIMIDINE DERIVATIVES, PHARMACEUTICAL AGENT CONTAINING SAID COMPOUNDS, USE AND METHOD FOR MAKING SAME | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2004-07-21 | — | — | EP | disclosed |
| WO-2003032997-A1 | PYRIMIDINE DERIVATIVES, PHARMACEUTICAL AGENT CONTAINING SAID COMPOUNDS, USE AND METHOD FOR MAKING SAME | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-04-24 | — | — | WO | disclosed |