Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azd-1080. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 1.00 |
| ▸ | CDK7 | P50613 | 3/20 | 1.00 |
| ▸ | CDK1 | P06493 | 2/20 | 1.00 |
| ▸ | CDK2 | P24941 | 2/20 | 1.00 |
| ▸ | DYRK3 | O43781 | 1/20 | 1.00 |
| ▸ | CDK5 | Q00535 | 1/20 | 1.00 |
| ▸ | CAMK2G | Q13555 | 1/20 | 1.00 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 1.00 |
| ▸ | PIM3 | Q86V86 | 1/20 | 1.00 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 1.00 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 1.00 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 1.00 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 1.00 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 1.00 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 1.00 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 1.00 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azd-1080 SCHEMBL30298327 | 1.00 | CDK7 (1.00) | CDK7CDK1CDK2DYRK3GSK3B | |
| Azd-1080 SCHEMBL29374248 | 1.00 | CDK7 (1.00) | CDK7CDK1CDK2DYRK3GSK3B | |
| Azd-1080 SCHEMBL394519 | 1.00 | CDK7 (1.00) | CDK7CDK1CDK2DYRK3GSK3B | |
| Azd-1080 SCHEMBL29361806 | 1.00 | CDK7 (1.00) | CDK7CDK1CDK2DYRK3GSK3B | |
| Azd-1080 SCHEMBL395245 | 0.99 | CDK7 (0.98) | CDK7CDK1CDK2DYRK3GSK3B | |
| Azd-1080 SCHEMBL2684436 | 0.95 | CDK7 (0.91) | CDK7CDK1CDK2DYRK3GSK3B | |
| Azd-1080 SCHEMBL27755135 | 0.95 | CDK7 (0.91) | CDK7CDK1CDK2DYRK3GSK3B | |
| Azd-1080 SCHEMBL2685061 | 0.94 | CDK7 (0.88) | CDK7CDK1CDK2DYRK3GSK3B | |
| Azd-1080 SCHEMBL2685991 | 0.93 | CDK7 (0.86) | CDK7CDK1CDK2DYRK3GSK3B | |
| Azd-1080 SCHEMBL2686165 | 0.93 | CDK7 (0.86) | CDK7CDK1CDK2DYRK3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183247-B1 | NEW CRYSTALLINE FORMS OF 2 -HYDROXY- 3- [5- (MORPHOLIN- 4- YLMETHYL) PYRIDIN-2-YL]1H- INDOLE- 5 -CARBONITRILE CITRATE | ASTRAZENECA AB (SE) | 2012-05-16 | — | — | EP | claimed |