Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.61 |
| ▸ | CTSA | P10619 | 4/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 4/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1389741 | 0.93 | GPBAR1 (0.67) | GPBAR1CTSAPSEN1PSEN2APH1B | |
| SCHEMBL10241016 | 0.93 | GPBAR1 (0.67) | GPBAR1CTSAPSEN1PSEN2APH1B | |
| SCHEMBL1389740 | 0.93 | GPBAR1 (0.67) | GPBAR1CTSAPSEN1PSEN2APH1B | |
| SCHEMBL1389913 | 0.89 | GPBAR1 (0.67) | GPBAR1CTSA | |
| SCHEMBL365003 | 0.89 | GPBAR1 (0.67) | GPBAR1CTSA | |
| SCHEMBL363141 | 0.84 | GPBAR1 (0.54) | GPBAR1CTSACTSSCTSK | |
| SCHEMBL10240885 | 0.84 | GPBAR1 (0.54) | GPBAR1CTSACTSSCTSK | |
| SCHEMBL363140 | 0.84 | GPBAR1 (0.54) | GPBAR1CTSACTSSCTSK | |
| SCHEMBL1390079 | 0.84 | GPBAR1 (0.53) | GPBAR1CTSAPSEN1PSEN2APH1B | |
| SCHEMBL363578 | 0.84 | GPBAR1 (0.86) | GPBAR1CTSAPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |