Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.69 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL360154 | 0.88 | PIK3CD (0.88) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL357441 | 0.88 | PIK3CD (0.88) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL357442 | 0.88 | PIK3CD (0.88) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL357892 | 0.82 | PIK3CD (1.00) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL29439887 | 0.82 | PIK3CD (1.00) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL358472 | 0.79 | PIK3CD (0.78) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL358471 | 0.79 | PIK3CD (0.78) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL360143 | 0.79 | PIK3CD (0.78) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL359207 | 0.75 | PIK3CD (0.88) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL357996 | 0.75 | PIK3CD (0.80) | PIK3CDPIK3CBPIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593455-A1 | PURINE COMPOUNDS SELECTIVE FOR I3 P110 DELTA, AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | claimed |
| WO-2012007493-A1 | PURINE COMPOUNDS SELECTIVE FOR ΡI3Κ P110 DELTA, AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | claimed |