Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.78 |
| ▸ | BRD4 | O60885 | 3/20 | 0.74 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.74 |
| ▸ | RAD52 | P43351 | 1/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31416067 | 1.00 | PLK1 (0.78) | PLK1BRD4BRDTRAD52ALK | |
| SCHEMBL30135997 | 0.88 | PLK1 (0.62) | PLK1BRD4BRDTRAD52 | |
| SCHEMBL1675657 | 0.88 | PLK1 (1.00) | PLK1BRD4BRDTRAD52ALK | |
| Tak-960 SCHEMBL1560793 | 0.86 | PLK1 (1.00) | PLK1BRD4BRDTRAD52 | |
| Tak-960 SCHEMBL30047124 | 0.86 | PLK1 (1.00) | PLK1BRD4BRDTRAD52 | |
| Tak-960 SCHEMBL29361245 | 0.86 | PLK1 (1.00) | PLK1BRD4BRDTRAD52 | |
| Tak-960 SCHEMBL23277130 | 0.85 | PLK1 (0.99) | PLK1BRD4BRDTRAD52 | |
| Tak-960 SCHEMBL30046005 | 0.85 | PLK1 (0.99) | PLK1BRD4BRDTRAD52 | |
| Tak-960 SCHEMBL30237758 | 0.85 | PLK1 (0.99) | PLK1BRD4BRDTRAD52 | |
| SCHEMBL1675786 | 0.85 | PLK1 (1.00) | PLK1BRD4BRDTRAD52ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197442-A1 | POLO-LIKE KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009042806-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |