Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 12/20 | 0.57 |
| ▸ | GRM8 | O00222 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ATP4A | P20648 | 2/20 | 0.34 |
| ▸ | ATP4B | P51164 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370274 | 0.92 | GRM4 (0.65) | GRM4GRM8ALDH1A1GAAMAPT | |
| SCHEMBL370650 | 0.92 | GRM4 (0.65) | GRM4GRM8ALDH1A1GAAMAPT | |
| SCHEMBL370490 | 0.83 | GRM4 (0.67) | GRM4GRM8ALDH1A1GAAMAPT | |
| SCHEMBL369775 | 0.78 | GRM4 (0.69) | GRM4GRM8ALDH1A1GAAMAPT | |
| SCHEMBL369427 | 0.78 | GRM4 (0.72) | GRM4GRM8ALDH1A1MAPTRAB9A | |
| SCHEMBL370275 | 0.76 | GRM4 (0.73) | GRM4GRM8ALDH1A1MAPTATP4A | |
| SCHEMBL365856 | 0.76 | GRM4 (0.69) | GRM4GRM8ALDH1A1KCNH2PDE4B | |
| SCHEMBL369134 | 0.75 | GRM4 (0.68) | GRM4GRM8KCNH2PDE4BKDR | |
| SCHEMBL367907 | 0.74 | GRM4 (0.65) | GRM4GRM8ALDH1A1GAAMAPT | |
| SCHEMBL369152 | 0.73 | GRM4 (1.00) | GRM4GRM8ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595986-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-29 | — | — | EP | claimed |
| WO-2012009009-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | claimed |