Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | CA3 | P07451 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 11/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenol SCHEMBL247463 | 0.89 | CA12 (0.69) | TDP1CA12CA1CA2GLA | |
| Phenol SCHEMBL28206744 | 0.89 | CA12 (0.69) | TDP1CA12CA1CA2GLA | |
| Phenol SCHEMBL919188 | 0.89 | CA12 (0.69) | TDP1CA12CA1CA2GLA | |
| Phenol SCHEMBL28324303 | 0.89 | CA12 (0.69) | TDP1CA12CA1CA2GLA | |
| Phenol SCHEMBL10697808 | 0.87 | CA12 (0.65) | TDP1CA12CA1CA2GLA | |
| Phenol SCHEMBL28348043 | 0.87 | CA12 (0.65) | TDP1CA12CA1CA2GLA | |
| Phenol SCHEMBL28207259 | 0.87 | CA12 (0.65) | TDP1CA12CA1CA2GLA | |
| Phenol SCHEMBL9754756 | 0.87 | CA12 (0.65) | TDP1CA12CA1CA2GLA | |
| Phenol SCHEMBL10934675 | 0.87 | CA12 (0.65) | TDP1CA12CA1CA2GLA | |
| Phenol SCHEMBL27854922 | 0.87 | CA12 (0.65) | TDP1CA12CA1CA2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116790610-A | Gene for treating bone diseases and gene therapeutic drug using AAV as vector | 四川大学 | 2023-09-22 | — | — | CN | disclosed |
| CN-114574502-B | Novel coronavirus vaccine using replication-defective adeno-associated virus as vector | 四川大学 | 2023-07-14 | — | — | CN | disclosed |
| CN-114574502-A | Novel coronavirus vaccine taking replication-defective adeno-associated virus as vector | 四川大学 | 2022-06-03 | — | — | CN | disclosed |
| CN-114380922-A | Fusion protein for generating point mutation in cell, preparation and application thereof | 中国科学院上海营养与健康研究所 | 2022-04-22 | — | — | CN | disclosed |
| CN-113106144-A | DNA fragment targeted enrichment method and application thereof in genome targeted sequencing | 中南大学湘雅二医院 | 2021-07-13 | — | — | CN | disclosed |
| CN-112204139-A | General method for extracting nucleic acid molecules from different populations of one or more types of microorganisms in a sample | 太阳基因组学公司 | 2021-01-08 | — | — | CN | disclosed |
| US-10883149-B2 | Aptamers with binding affinity to norovirus | NORTH CAROLINA STATE UNIVERSITY (US) | 2021-01-05 | — | — | US | disclosed |
| CN-109055378-B | Production application of single-subunit RNA polymerase KP34RP in long-chain mRNA synthesis | 武汉核圣生物技术有限公司 | 2020-11-13 | — | — | CN | disclosed |
| CN-111778563-A | Construction method of cell Hi-C sequencing library | 天津诺禾致源生物信息科技有限公司 | 2020-10-16 | — | — | CN | disclosed |
| US-20190233905-A1 | APTAMERS WITH BINDING AFFINITY TO NOROVIRUS | NORTH CAROLINA STATE UNIVERSITY (US) | 2019-08-01 | — | — | US | disclosed |
| US-20120122958-A1 | TRANSCRIPTIONAL REPRESSION LEADING TO PARKINSON'S DISEASE | VALTED, LLC | 2012-05-17 | — | — | US | disclosed |
| CN-102409031-A | Novel beta-galactoside-alpha 2, 3-sialyltransferase, gene encoding same, and method for producing same | JAPAN TOBACCO INC | 2012-04-11 | — | — | CN | disclosed |
| US-8071296-B2 | Nucleic acid interaction analysis | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2011-12-06 | — | — | US | disclosed |
| CN-101203606-B | Novel beta-galactoside-alpha 2, 3-sialyltransferase, gene encoding same, and method for producing same | JAPAN TOBACCO INC | 2011-10-26 | — | — | CN | disclosed |
| WO-2009129619-A1 | APTAMERS FOR DETECTION AND IMAGING OF APOPTOSIS | ALBERTA CANCER BOARD (CA) | 2009-10-29 | — | — | WO | disclosed |
| CN-101400789-A | Novel beta-galactoside alpha- 2,6-sialyltransferase, gene coding for the transferase and process for producing the same | JAPAN TOBACCO INC (JP) | 2009-04-01 | — | — | CN | disclosed |
| CN-101203606-A | Novel beta-galactoside-alpha 2, 3-sialyltransferase, gene encoding same, and method for producing same | JAPAN TOBACCO INC (JP) | 2008-06-18 | — | — | CN | disclosed |
| US-20070238101-A1 | Nucleic acid interaction analysis | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2007-10-11 | — | — | US | disclosed |
| WO-2007106047-A1 | NUCLEIC ACID INTERACTION ANALYSIS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2007-09-20 | — | — | WO | disclosed |
| EP-1835038-A1 | Nucleic acid interaction analysis | Agency for Science, Technology and Research (SG) | 2007-09-19 | — | — | EP | disclosed |