Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | P2RY1 | P47900 | 14/20 | 0.48 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.44 |
| ▸ | GOT1 | P17174 | 1/20 | 0.44 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3705741 | 0.99 | NTRK1 (0.53) | NTRK1P2RY1STING1NPC1RAB9A | |
| SCHEMBL3713779 | 0.93 | NTRK1 (0.45) | NTRK1P2RY1STING1TRPV1 | |
| SCHEMBL15052899 | 0.92 | NTRK1 (0.52) | NTRK1P2RY1STING1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL3699079 | 0.92 | NTRK1 (0.44) | NTRK1P2RY1STING1TRPV1 | |
| SCHEMBL3705702 | 0.89 | BRAF (0.51) | P2RY1STING1GOT1TRPV1 | |
| SCHEMBL3703968 | 0.89 | MAPT (0.49) | NTRK1P2RY1NPC1RAB9ATRPV1 | |
| SCHEMBL3707202 | 0.89 | KDR (0.46) | NTRK1P2RY1STING1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL3698985 | 0.88 | MAPT (0.48) | NTRK1P2RY1NPC1RAB9ATRPV1 | |
| Hydrochloric Acid SCHEMBL3710714 | 0.88 | BRAF (0.51) | P2RY1STING1GOT1TRPV1 | |
| SCHEMBL3699351 | 0.88 | NTRK1 (0.41) | NTRK1P2RY1P2RY14P2RY2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8648086-B2 | 5,6-bicyclic heteroaryl-containing urea compounds as kinase inhibitors | ASCEPION PHARMACEUTICALS, INC. (CN) | 2014-02-11 | — | — | US | claimed |
| US-20120122895-A1 | 5,6-BICYCLIC HETEROARYL-CONTAINING UREA COMPOUNDS AS KINASE INHIBITORS | JIANG, SHAN | 2012-05-17 | — | — | US | claimed |
| US-8648086-B2 | 5,6-bicyclic heteroaryl-containing urea compounds as kinase inhibitors | ASCEPION PHARMACEUTICALS, INC. (CN) | 2014-02-11 | — | — | US | disclosed |
| US-20120122895-A1 | 5,6-BICYCLIC HETEROARYL-CONTAINING UREA COMPOUNDS AS KINASE INHIBITORS | JIANG, SHAN | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122895-A1 | 5,6-BICYCLIC HETEROARYL-CONTAINING UREA COMPOUNDS AS KINASE INHIBITORS | FLT3, CSF1R, EPHA2 | NTRK1 817/4885P2RY1 441/4885STING1 1679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.