Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 19/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | GRM8 | O00222 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL360277 | 0.97 | GRM4 (0.64) | GRM4KCNH2GRM8NPC1PKM | |
| SCHEMBL360655 | 0.92 | GRM4 (0.61) | GRM4KCNH2 | |
| SCHEMBL370211 | 0.87 | GRM4 (0.67) | GRM4KCNH2GRM8NPC1PKM | |
| SCHEMBL368818 | 0.84 | GRM4 (0.63) | GRM4KCNH2GRM8NPC1PKM | |
| SCHEMBL369716 | 0.84 | GRM4 (0.63) | GRM4KCNH2GRM8NPC1PKM | |
| SCHEMBL368817 | 0.84 | GRM4 (0.63) | GRM4KCNH2GRM8NPC1PKM | |
| SCHEMBL370251 | 0.83 | GRM4 (0.59) | GRM4KCNH2GRM8NPC1PKM | |
| SCHEMBL370460 | 0.82 | GRM4 (0.71) | GRM4KCNH2GRM8NPC1PKM | |
| SCHEMBL370372 | 0.80 | GRM4 (0.66) | GRM4KCNH2GRM8NPC1PKM | |
| SCHEMBL369375 | 0.80 | GRM4 (0.55) | GRM4KCNH2GRM8NPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593277-A2 | NOVEL FUSED PYRAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX Pharma S.A. (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012009000-A2 | NOVEL FUSED PYRAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | disclosed |