Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 13/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3704125 | 1.00 | PTPRB (0.50) | PTPRBKDM4ENPC1SLC6A3MAPT | |
| SCHEMBL3715735 | 0.90 | PTPRB (0.49) | PTPRBKDM4ENPC1SLC6A3 | |
| SCHEMBL27921824 | 0.90 | PTPRB (0.49) | PTPRBKDM4ENPC1SLC6A3 | |
| SCHEMBL19945964 | 0.90 | PTPRB (0.49) | PTPRBKDM4ENPC1SLC6A3 | |
| SCHEMBL16079944 | 0.88 | PTPRB (0.56) | PTPRBKDM4ENPC1 | |
| SCHEMBL3693428 | 0.87 | PTPRB (0.47) | PTPRBKDM4ENPC1SLC6A3MAPT | |
| SCHEMBL500500 | 0.85 | PTPRB (0.49) | PTPRBKDM4EMAPT | |
| SCHEMBL16081630 | 0.85 | PTPRB (0.57) | PTPRBKDM4E | |
| SCHEMBL500755 | 0.85 | PTPRB (0.69) | PTPRB | |
| SCHEMBL500756 | 0.85 | PTPRB (0.69) | PTPRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451279-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR PREVENTING METASTASIS OF CANCER CELLS | Akebia Therapeutics Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2010081172-A1 | METHODS FOR TREATING VASCULAR LEAK SYNDROME | AKEBIA THERAPEUTICS INC. (US) | 2010-07-15 | — | — | WO | disclosed |