Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.63 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.63 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.42 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.40 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.40 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.40 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2338268 | 0.96 | LPAR1 (0.68) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL3711135 | 0.94 | LPAR1 (0.57) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL3709240 | 0.94 | LPAR1 (0.58) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL3700613 | 0.93 | LPAR1 (0.61) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL3707585 | 0.91 | LPAR1 (0.53) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL3702564 | 0.91 | LPAR1 (0.59) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL3714467 | 0.91 | LPAR1 (0.61) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL3712525 | 0.90 | LPAR1 (0.57) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL3712768 | 0.90 | LPAR1 (0.58) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL3702336 | 0.90 | LPAR1 (0.60) | LPAR1LPAR3LPAR2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | claimed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |