Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 13/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15260678 | 0.91 | RXFP1 (0.41) | ACHEMAPTSMN1; SMN2TP53RXFP1 | |
| SCHEMBL370449 | 0.84 | MAPT (0.42) | ACHEMAPTALDH1A1KDM4E | |
| SCHEMBL370746 | 0.84 | GRM4 (0.41) | ACHESMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL369101 | 0.81 | MAPT (0.47) | MAPTSMN1; SMN2TP53RXFP1ALDH1A1 | |
| SCHEMBL15261475 | 0.80 | RXFP1 (0.42) | ACHEMAPTSMN1; SMN2TP53RXFP1 | |
| SCHEMBL370822 | 0.75 | NPC1 (0.40) | ACHEMAPTSMN1; SMN2TP53RXFP1 | |
| SCHEMBL368910 | 0.73 | GRM4 (0.42) | ACHEMAPTSMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL369977 | 0.72 | KDM4E (0.44) | ACHEMAPTALDH1A1KDM4E | |
| SCHEMBL366960 | 0.72 | MAPT (0.44) | MAPTSMN1; SMN2TP53RXFP1ALDH1A1 | |
| SCHEMBL370384 | 0.72 | GRM4 (0.43) | ACHEMAPTSMN1; SMN2TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593277-A2 | NOVEL FUSED PYRAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX Pharma S.A. (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012009000-A2 | NOVEL FUSED PYRAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | disclosed |