Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.59 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.59 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3282802 | 0.91 | RXFP1 (0.69) | RXFP1ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL3060904 | 0.88 | RXFP1 (0.67) | RXFP1ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL1718496 | 0.86 | RXFP1 (0.75) | RXFP1ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL1720133 | 0.84 | RXFP1 (0.71) | RXFP1ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL1719430 | 0.84 | RXFP1 (0.72) | RXFP1ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL1718538 | 0.83 | RXFP1 (0.68) | RXFP1ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL1719378 | 0.83 | USP2 (0.64) | RXFP1ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL5658010 | 0.82 | RXFP1 (0.59) | RXFP1ALDH1A1KDM4EHPGDAPOBEC3A | |
| SCHEMBL1717682 | 0.82 | RXFP1 (0.67) | RXFP1ALDH1A1MAPK1APOBEC3ACTDSP1 | |
| SCHEMBL1718584 | 0.82 | RXFP1 (0.62) | RXFP1ALDH1A1KDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086040-A1 | PYRAZOLO-PYRIMIDINES FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086040-A1 | PYRAZOLO-PYRIMIDINES FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-08-05 | — | — | WO | disclosed |