Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | DUSP1 | P28562 | 1/20 | 1.00 |
| ▸ | DUSP6 | Q16828 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | BCHE | P06276 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3698650 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6CYP2C19DUSP1DUSP6 | |
| SCHEMBL3698118 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6CYP2C19DUSP1DUSP6 | |
| SCHEMBL6986631 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6CYP2C19DUSP1DUSP6 | |
| SCHEMBL3698651 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6CYP2C19DUSP1DUSP6 | |
| SCHEMBL30461402 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6CYP2C19DUSP1DUSP6 | |
| SCHEMBL3698122 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP2D6CYP2C19DUSP1DUSP6 | |
| Hydrochloric Acid SCHEMBL29853655 | 0.99 | CYP1A2 (0.97) | CYP1A2CYP2D6CYP2C19DUSP1DUSP6 | |
| Hydrochloric Acid SCHEMBL29851512 | 0.99 | CYP1A2 (0.97) | CYP1A2CYP2D6CYP2C19DUSP1DUSP6 | |
| Hydrochloric Acid SCHEMBL6116091 | 0.99 | CYP1A2 (0.97) | CYP1A2CYP2D6CYP2C19DUSP1DUSP6 | |
| Hydrochloric Acid SCHEMBL6116098 | 0.99 | CYP1A2 (0.97) | CYP1A2CYP2D6CYP2C19DUSP1DUSP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682919-B2 | Small molecule inhibitors of Dusp6 and uses therefor | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-06-20 | — | — | US | disclosed |
| US-20160355459-A1 | Small Molecule Inhibitors of Dusp6 and Uses Therefor | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2016-12-08 | — | — | US | disclosed |
| US-9439877-B2 | Small molecule inhibitors of Dusp6 and uses therefor | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2016-09-13 | — | — | US | disclosed |
| US-20160113889-A1 | Small Molecule Inhibitors of Dusp6 and Uses Therefor | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2016-04-28 | — | — | US | disclosed |
| US-9127016-B2 | Small molecule inhibitors of Dusp6 and uses therefor | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2015-09-08 | — | — | US | disclosed |
| US-20120122992-A1 | SMALL MOLECULE INHIBITORS OF Dusp6 AND USES THEREFOR | University of Pittsburgh-Of the Commonwealth Syste (US) | 2012-05-17 | — | — | US | disclosed |
| WO-2010108058-A2 | SMALL MOLECULE INHIBITORS OF DUSP6 AND USES THEREFOR | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2010-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160113889-A1 | Small Molecule Inhibitors of Dusp6 and Uses Therefor | DUSP26, DUSP6, DUSP2 | CYP1A2 4787/4885CYP2D6 4250/4885CYP2C19 4847/4885 |
| US-20160355459-A1 | Small Molecule Inhibitors of Dusp6 and Uses Therefor | DUSP26, DUSP6, DUSP2 | CYP1A2 4787/4885CYP2D6 4250/4885CYP2C19 4847/4885 |
| US-20120122992-A1 | SMALL MOLECULE INHIBITORS OF Dusp6 AND USES THEREFOR | DUSP26, DUSP6, DUSP2 | CYP1A2 4787/4885CYP2D6 4250/4885CYP2C19 4847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.