Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 20/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL358727 | 0.90 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL358982 | 0.88 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL359168 | 0.87 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL360049 | 0.87 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL359781 | 0.87 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL359735 | 0.87 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL360614 | 0.87 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL358853 | 0.87 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL359104 | 0.86 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL359112 | 0.86 | IRAK4 (0.80) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593457-A1 | PYRAZOLO [1, 5A]PYRIMIDINE AND THIENO [3, 2B]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007375-A1 | PYRAZOLO [1, 5A] PYRIMIDINE AND THIENO [3, 2B] PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |