Sugi Predict

Sugi Predict / Compounds / SCHEMBL3705385

SCHEMBL3705385

SCHEMBL3705385

CC(=O)C1=C(O)C(=O)N(CCc2ccc(Br)cc2)C1c1ccc(Br)cc1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ USP7 Q93009 1/20 0.79
▸ MEN1 O00255 4/20 0.67
▸ KMT2A Q03164 4/20 0.67
▸ TP53 P04637 1/20 0.61
▸ MDM2 Q00987 1/20 0.61
▸ RXFP1 Q9HBX9 4/20 0.60
▸ ATM Q13315 1/20 0.60
▸ KDM4E B2RXH2 4/20 0.56
▸ ALDH1A1 P00352 3/20 0.55
▸ HPGD P15428 2/20 0.55
▸ CCR1 P32246 1/20 0.55
▸ CCR2 P41597 1/20 0.55
▸ TSHR P16473 2/20 0.54
▸ TDP1 Q9NUW8 1/20 0.54
▸ MAPT P10636 1/20 0.53
▸ LMNA P02545 1/20 0.53
▸ ALOX15 P16050 1/20 0.53
▸ L3MBTL1 Q9Y468 1/20 0.52
▸ FPR1 P21462 1/20 0.51
▸ HTT P42858 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3707178 0.94 USP7 (0.78) USP7MEN1KMT2ATP53MDM2
SCHEMBL3716480 0.94 USP7 (0.78) USP7MEN1KMT2ATP53MDM2
SCHEMBL3709046 0.94 USP7 (0.78) USP7MEN1KMT2ATP53MDM2
SCHEMBL3707749 0.94 USP7 (0.71) USP7MEN1KMT2ATP53MDM2
SCHEMBL3705340 0.94 MEN1 (0.78) USP7MEN1KMT2ATP53MDM2
SCHEMBL3714403 0.92 USP7 (0.69) USP7MEN1KMT2ATP53MDM2
SCHEMBL3706307 0.92 USP7 (0.69) USP7MEN1KMT2ATP53MDM2
SCHEMBL3704238 0.92 USP7 (0.68) USP7MEN1KMT2ATP53MDM2
SCHEMBL3704381 0.91 MEN1 (0.70) USP7MEN1KMT2ATP53MDM2
SCHEMBL3708805 0.90 USP7 (0.66) USP7MEN1KMT2ATP53MDM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010081783-A1 NOVEL SPECIFIC INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS HYBRIGENICS SA (FR) 2010-07-22 — — WO claimed
EP-2208725-A1 Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications Hybrigenics S.A. (FR) 2010-07-21 — — EP claimed
US-20220125760-A1 USE OF USP7 INHIBITORS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) UNIVERSITÉ PAUL SABATIER TOULOUSE III (FR) 2022-04-28 — — US disclosed
EP-3923987-A1 USE OF USP7 INHIBITORS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) 2021-12-22 — — EP disclosed
WO-2020165315-A1 USE OF USP7 INHIBITORS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2020-08-20 — — WO disclosed
WO-2010081783-A1 NOVEL SPECIFIC INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS HYBRIGENICS SA (FR) 2010-07-22 — — WO disclosed
WO-2010081783-A1 NOVEL SPECIFIC INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS HYBRIGENICS SA (FR) 2010-07-22 — — WO disclosed
EP-2208725-A1 Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications Hybrigenics S.A. (FR) 2010-07-21 — — EP disclosed
EP-2208725-A1 Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications Hybrigenics S.A. (FR) 2010-07-21 — — EP disclosed